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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HELQ
All Species:
5.76
Human Site:
S227
Identified Species:
12.67
UniProt:
Q8TDG4
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8TDG4
NP_598375.2
1101
124175
S227
E
R
D
W
K
S
S
S
H
N
T
V
N
E
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001104832
1101
124326
S227
E
R
D
W
K
S
S
S
H
N
T
V
N
E
E
Dog
Lupus familis
XP_544959
1072
121306
Q217
N
S
T
E
H
H
Q
Q
I
D
D
P
C
S
K
Cat
Felis silvestris
Mouse
Mus musculus
Q2VPA6
1069
119080
S218
N
V
R
A
A
S
E
S
S
R
R
K
S
L
K
Rat
Rattus norvegicus
NP_001014156
1065
118695
R217
G
S
S
E
A
S
R
R
R
S
I
K
D
C
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517710
972
107104
A145
S
G
G
R
C
Q
R
A
R
G
Q
H
R
A
G
Chicken
Gallus gallus
XP_420565
1048
116823
C217
K
S
S
K
G
S
V
C
D
S
C
K
S
V
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_691411
1010
112859
R183
K
P
H
P
K
A
R
R
S
M
K
D
H
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648178
1051
117314
W220
S
L
L
D
P
V
N
W
E
T
Q
A
F
A
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001022911
923
102951
K96
L
K
R
S
S
L
S
K
L
A
D
G
F
R
T
Sea Urchin
Strong. purpuratus
XP_796097
1147
129034
H263
C
V
N
T
K
Y
N
H
F
M
S
D
E
H
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
96.9
83.1
N.A.
75.1
75.3
N.A.
56.6
61.5
N.A.
54.7
N.A.
36.9
N.A.
32.7
40.7
Protein Similarity:
100
N.A.
98.7
90.2
N.A.
84.4
84.9
N.A.
68
74.3
N.A.
71.1
N.A.
56.9
N.A.
51.4
59.7
P-Site Identity:
100
N.A.
100
0
N.A.
13.3
6.6
N.A.
0
6.6
N.A.
6.6
N.A.
0
N.A.
6.6
6.6
P-Site Similarity:
100
N.A.
100
13.3
N.A.
26.6
20
N.A.
6.6
26.6
N.A.
33.3
N.A.
13.3
N.A.
13.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
19
10
0
10
0
10
0
10
0
19
0
% A
% Cys:
10
0
0
0
10
0
0
10
0
0
10
0
10
10
0
% C
% Asp:
0
0
19
10
0
0
0
0
10
10
19
19
10
0
10
% D
% Glu:
19
0
0
19
0
0
10
0
10
0
0
0
10
19
19
% E
% Phe:
0
0
0
0
0
0
0
0
10
0
0
0
19
0
0
% F
% Gly:
10
10
10
0
10
0
0
0
0
10
0
10
0
0
10
% G
% His:
0
0
10
0
10
10
0
10
19
0
0
10
10
10
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% I
% Lys:
19
10
0
10
37
0
0
10
0
0
10
28
0
0
28
% K
% Leu:
10
10
10
0
0
10
0
0
10
0
0
0
0
19
10
% L
% Met:
0
0
0
0
0
0
0
0
0
19
0
0
0
0
0
% M
% Asn:
19
0
10
0
0
0
19
0
0
19
0
0
19
0
0
% N
% Pro:
0
10
0
10
10
0
0
0
0
0
0
10
0
0
0
% P
% Gln:
0
0
0
0
0
10
10
10
0
0
19
0
0
0
0
% Q
% Arg:
0
19
19
10
0
0
28
19
19
10
10
0
10
10
0
% R
% Ser:
19
28
19
10
10
46
28
28
19
19
10
0
19
10
10
% S
% Thr:
0
0
10
10
0
0
0
0
0
10
19
0
0
0
10
% T
% Val:
0
19
0
0
0
10
10
0
0
0
0
19
0
10
10
% V
% Trp:
0
0
0
19
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _